By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic examine on osteoarthritis has been conducted typically from the his tological and biochemical points of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical pressure has been proven to be the imperative think about the initiation of osteoarthritis. even though the precise method in which mechanical pressure results in the complete destruction of cartilage tissue continues to be doubtful, numerous new learn equipment have enabled us to realize a deeper realizing of the method of degeneration. In October 1997, we equipped a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up to date re seek, analysis, and therapy of osteoarthritis. The complaints of the symposium are provided right here in 5 sections: (1) Mechanical pressure and reactions of chondrocytes, equivalent to intracellular ion adjustments, alterations within the cytoskeleton, intracellular messenger platforms, free up of gasoline mediators, and alterations in electromechanical homes of cartilage; (2) sensible analysis of osteoarthritis by means of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising uncomplicated washout procedure and IL-1RA and MMP antagonists; (4) Cartilage fix through new grafting tech niques; and (5) difficulties following overall joint substitute. We basically wish that the complicated wisdom supplied during this quantity of complaints should be beneficial to our readers.
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NS, not significant Mechanical Stress on Chondrocytes 43 3. 1 Exp. d. , not determined. Cells were cultured in the basence or presence of a higher cyclic tensile stretch (see Table 1). Enzyme activity was measured using a Biotrak kit, and phosphate transferred per 15 min was compared with nonstretched controls at the indicated time. : SD of 6 wells). Three experiments are shown, using different preparations of bovine chondrocytes. inhibition was completely blocked by PDBu pretreatment (Fig. 6).
Cells were seeded at a density of 2 X 105 cells/ml in 96-well plates. Different concentrations of phorbol ester (PDBu) were added for 24 h. Data are expressed as the mean ± SD of 6 wells. 01. Results were similar in two additional experiments 42 K. Fukuda et al. s 6 + + + SIres + Inhibilor FIG. 5. Effect of a protein kinase C inhibitor on stress-mediated inhibition of proteoglycan synthesis. Cyclic tensile stretch (stress) was loaded on the chondrocytes in the absence (-) or presence (+) of a protein kinase C inhibitor (H7, l,uM) for 24h.
Regulation by hydrostatic pressure also involves mRNA levels of the PG core proteins [45,53]. Suifation, glycosylation, and protein synthesis were all markedly inhibited by continuous high (30-MPa) hydrostatic pressure. In addition, retarded migration in SDS-agarose gel electrophoresis and earlier elution on Sephacryl S1000 gel chromatography suggested a shift of aggrecans into a range of greater molecular weight. A slight increase observed in the relative length of GAG chains could explain this finding.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)